Ontology highlight
ABSTRACT:
SUBMITTER: Liang X
PROVIDER: S-EPMC4170602 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Liang Xiuming X Zeng Jiping J Wang Lixiang L Shen Li L Li Shuyan S Ma Lin L Ci Xinyu X Yu Jingya J Jia Mutian M Sun Yundong Y Liu Zhifang Z Liu Shili S Li Wenjuan W Yu Han H Chen Chunyan C Jia Jihui J
Oncotarget 20140701 14
Gastric epithelial cell malignant transformation induced by Helicobactor Pylori contributes to tumor development, but the underlying mechanisms for this remain unclear. Here we demonstrate that RBP2, a newly identified histone demethylase, can be induced by CagA via PI3K/AKT-Sp1 pathway depending on AKT phosphorylation. Sp1 directly binds to RBP2 promoter and enhances its expression then the upregulated RBP2 significantly increases Cyclin D1 transcription, which contributes to gastric epithelial ...[more]