Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration.

ABSTRACT: Currently there is a lack of targeted therapies that lead to long-term attenuation or regression of disease in patients with advanced clear cell renal cell carcinoma (ccRCC). Our group has implemented a high-throughput genetic analysis coupled with a high-throughput proliferative screen in order to investigate the genetic contributions of a large cohort of overexpressed genes at the functional level in an effort to better understand factors involved in tumor initiation and progression. Patient gene array analysis identified transcripts that are consistently elevated in patient ccRCC as compared to matched normal renal tissues. This was followed by a high-throughput lentivirus screen, independently targeting 195 overexpressed transcripts identified in the gene array in four ccRCC cell lines

SUBMITTER: Von Roemeling CA 

PROVIDER: S-EPMC4170622 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature