Prospective study of common variants in CX3CR1 and risk of macular degeneration: pooled analysis from 5 long-term studies.

ABSTRACT:

Importance

The CX3CR1 gene is implicated as a candidate gene for age-related macular degeneration (AMD) through several lines of evidence. There is uncertainty, however, as to whether common genetic variants in CX3CR1 alter risk of AMD, since prior studies have been inconsistent and mostly limited to evaluation of 2 nonsynonymous variants, T280M (rs3732378) and V249I (rs3732379).

Objective

To determine if common variants in CX3CR1 predict future risk of AMD.

Design, setting, and participants

Prospective nested case-control study within 5 large study populations with long-term follow-up. We measured genotypes for T280M, V249I, and 13 other common single-nucleotide polymorphisms (SNPs) of the CX3CR1 gene among people who developed AMD (n = 1110, including 369 with neova

SUBMITTER: Schaumberg DA 

PROVIDER: S-EPMC4170669 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature