Nocturnal rapid eye movement sleep latency for identifying patients with narcolepsy/hypocretin deficiency.

ABSTRACT:

Importance

Narcolepsy, a disorder associated with HLA-DQB1*06:02 and caused by hypocretin (orexin) deficiency, is diagnosed using the Multiple Sleep Latency Test (MSLT) following nocturnal polysomnography (NPSG). In many patients, a short rapid eye movement sleep latency (REML) during the NPSG is also observed but not used diagnostically.

Objective

To determine diagnostic accuracy and clinical utility of nocturnal REML measures in narcolepsy/hypocretin deficiency.

Design, setting, and participants

Observational study using receiver operating characteristic curves for NPSG REML and MSLT findings (sleep studies performed between May 1976 and September 2011 at university medical centers in the United States, China, Korea, and Europe) to determine optimal diagnostic cutof

SUBMITTER: Andlauer O 

PROVIDER: S-EPMC4170796 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature