The adaptor protein Swiprosin-1/EFhd2 is dispensable for platelet function in mice.

ABSTRACT:

Background

Platelets are anuclear cell fragments derived from bone marrow megakaryocytes that safeguard vascular integrity, but may also cause pathological vessel occlusion. Reorganizations of the platelet cytoskeleton and agonist-induced intracellular Ca2+-mobilization are crucial for platelet hemostatic function. EF-hand domain containing 2 (EFhd2, Swiprosin-1) is a Ca2+-binding cytoskeletal adaptor protein involved in actin remodeling in different cell types, but its function in platelets is unknown.

Objective

Based on the described functions of EFhd2 in immune cells, we tested the hypothesis that EFhd2 is a crucial adaptor protein for platelet function acting as a regulator of Ca2+-mobilization and cytoskeletal rearrangements.

Methods and results

We generated EFhd

SUBMITTER: Morowski M 

PROVIDER: S-EPMC4170979 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature