DNA-repair pathway inhibitors for the treatment of ovarian cancer.

ABSTRACT:

Background

Ovarian cancer is the sixth most common cancer and seventh most common cause of cancer death in women world-wide.Three-quarters of women present when the disease has spread through-put the abdomen (stage III or IV) and treatment consists of a combination of debulking surgery and platinum-based chemotherapy, with or without taxanes. Although initial responses to chemotherapy are often good, most women will relapse and require further chemotherapy and will eventually develop resistance to chemotherapy agents. Increased understanding about the molecular basis of ovarian cancer has lead to the development of novel agents, which work in different ways to conventional chemotherapy. These include DNA-repair pathway inhibitors, the commonest of which are the PARP (poly (ADP-ribo

SUBMITTER: Martinek I 

PROVIDER: S-EPMC4170994 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature