Medical interventions for high grade vulval intraepithelial neoplasia.

ABSTRACT:

Background

Vulval intraepithelial neoplasia (VIN) is a pre-malignant condition of the vulval skin; its incidence is increasing in women under 50 years. VIN is graded histologically as low grade or high grade. High grade VIN is associated with infection with human papilloma virus (HPV) infection and may progress to invasive disease. There is no consensus on the optimal management of high grade VIN. The high morbidity and high relapse rate associated with surgical interventions call for a formal appraisal of the evidence available for less invasive but effective interventions for high grade VIN.

Objectives

To evaluate the effectiveness and safety of medical interventions for high grade VIN.

Search strategy

We searched the Cochrane Gynaecological Cancer Group Trials Regi

SUBMITTER: Pepas L 

PROVIDER: S-EPMC4170998 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature