Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.

ABSTRACT: Increased immunoglobulin G (IgG) response to dietary antigens can be associated with gastrointestinal dysfunction and autoimmunity. The underlying processes contributing to these adverse reactions remain largely unknown, and it is likely that genetic factors play a role. Here, we estimate heritability and attempt to localize genetic factors influencing IgG antibody levels against food-derived antigens using an integrative genomics approach. IgG antibody levels were determined by ELISA in >1,300 Mexican Americans for the following food antigens: wheat gliadin; bovine casein; and two forms of bovine serum albumin (BSA-a and BSA-b). Pedigree-based variance components methods were used to estimate additive genetic heritability (h(2) ), perform genome-wide association analyses, and identify tra

SUBMITTER: Rubicz R 

PROVIDER: S-EPMC4171053 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature