Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia.

ABSTRACT:

Purpose

This study aims to explore possible associations between polymorphisms of common SNP rs1136410 and rS1805405 in PARP1 gene and male infertility with spermatogenesis impairment.

Methods

The polymorphic distributions of SNP rs1136410 and rS1805405 were investigated by polymerase chain reaction and restriction fragment length polymorphism analysis in a Chinese cohort including 371 infertile patients with idiopathic azoospermia or oligospermia and 231 controls.

Results

Significant differences in the frequencies of allele and genotype of SNP rs1136410 were observed between patients with oligospermia and controls. The allele C (46.3 % vs. 36.4 %, P = 0.003) and genotype CC (22.6 % vs. 13.4 %, P = 0.014) significantly increased, whereas genotype TT (30 % vs. 40.7 %,

SUBMITTER: Chen H 

PROVIDER: S-EPMC4171409 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature