Temporal trends from 1986 to 2008 in overall survival of small cell lung cancer patients.

ABSTRACT:

Objectives

An assessment of temporal trends in patient survival is important to determine the progress toward patient outcomes and to reveal where advancements must be made. This study assessed temporal changes spanning 22years in demographics, clinical characteristics, and overall survival of small cell lung cancer (SCLC) patients.

Materials and methods

This analysis included 1032 SCLC patients spanning two time-periods from the H. Lee Moffitt Cancer Center and Research Institute: 1986-1999 (N=410) and 2000-2008 (N=622). Kaplan-Meier survival curves and log-rank statistics were used to assess survival rates across the two time-periods and multivariable Cox proportional hazards models were used to generate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

SUBMITTER: Schabath MB 

PROVIDER: S-EPMC4171454 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature