Microsatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial cancer.

ABSTRACT: Microsatellite instability (MSI) and aneuploidy are inversely related phenomena. We tested whether ploidy status influences the clinical impact of MSI in endometrioid endometrial cancer (EEC). We analyzed 167 EECs for MSI and ploidy. Tumors were classified in three categories according to MSI and ploidy status. Associations with clinicopathological and molecular variables, survival, and treatment response were assessed. All MSI tumors (23%) were scored as diploid, and 14% of microsatellite stable (MSS) tumors presented aneuploidy. MSI tumors associated with older age at diagnosis, non-obesity, high histological grade, and advanced surgical stage. MSS-aneuploid tumors also associated with higher grade and advanced stage. In multivariate survival analysis MSI did not influence disease-free s

SUBMITTER: Bilbao-Sieyro C 

PROVIDER: S-EPMC4171623 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature