Genetic variants in the SOX6 gene are associated with bone mineral density in both Caucasian and Chinese populations.

ABSTRACT:

Summary

Given the biological function of SOX6 and recent genome-wide association finding, we performed a fine-mapping association analyses to investigate the relationship between SOX6 and BMD both in Caucasian and Chinese populations. We identified many single-nucleotide polymorphisms (SNPs) within or near the SOX6 gene to be significantly associated with hip bone mineral density (BMD).

Introduction

SOX6 gene is an essential transcription factor in chondrogenesis and cartilage formation. Recent genome-wide association studies (GWAS) detected a SNP (rs7117858) located at the downstream of SOX6 significantly associated with hip BMD.

Methods

Given the biological function of SOX6 and the GWAS finding, we considered SOX6 as a new candidate for BMD and osteoporosis. Therefo

SUBMITTER: Yang TL 

PROVIDER: S-EPMC4171834 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature