A model of hippocampal spiking responses to items during learning of a context-dependent task.

ABSTRACT: Single unit recordings in the rat hippocampus have demonstrated shifts in the specificity of spiking activity during learning of a contextual item-reward association task. In this task, rats received reward for responding to different items dependent upon the context an item appeared in, but not dependent upon the location an item appears at. Initially, neurons in the rat hippocampus primarily show firing based on place, but as the rat learns the task this firing became more selective for items. We simulated this effect using a simple circuit model with discrete inputs driving spiking activity representing place and item followed sequentially by a discrete representation of the motor actions involving a response to an item (digging for food) or the movement to a different item (movement to

SUBMITTER: Raudies F 

PROVIDER: S-EPMC4172020 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature