Ebola hemorrhagic Fever: novel biomarker correlates of clinical outcome.

ABSTRACT:

Background

Ebola hemorrhagic fever (EHF) outbreaks occur sporadically in Africa and result in high rates of death. The 2000-2001 outbreak of Sudan virus-associated EHF in the Gulu district of Uganda led to 425 cases, of which 216 were laboratory confirmed, making it the largest EHF outbreak on record. Serum specimens from this outbreak had been preserved in liquid nitrogen from the time of collection and were available for analysis.

Methods

Available samples were tested using a series of multiplex assays to measure the concentrations of 55 biomarkers. The data were analyzed to identify statistically significant associations between the tested biomarkers and hemorrhagic manifestations, viremia, and/or death.

Results

Death, hemorrhage, and viremia were independently ass

SUBMITTER: McElroy AK 

PROVIDER: S-EPMC4172044 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature