Metagenomic assay for identification of microbial pathogens in tumor tissues.

ABSTRACT:

Unlabelled

Screening for thousands of viruses and other pathogenic microorganisms, including bacteria, fungi, and parasites, in human tumor tissues will provide a better understanding of the contributory role of the microbiome in the predisposition for, causes of, and therapeutic responses to the associated cancer. Metagenomic assays designed to perform these tasks will have to include rapid and economical processing of large numbers of samples, supported by straightforward data analysis pipeline and flexible sample preparation options for multiple input tissue types from individual patients, mammals, or environmental samples. To meet these requirements, the PathoChip platform was developed by targeting viral, prokaryotic, and eukaryotic genomes with multiple DNA probes in a microa

SUBMITTER: Baldwin DA 

PROVIDER: S-EPMC4172075 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature