Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality.

ABSTRACT:

Importance

The established chronic kidney disease (CKD) progression end point of end-stage renal disease (ESRD) or a doubling of serum creatinine concentration (corresponding to a change in estimated glomerular filtration rate [GFR] of −57% or greater) is a late event.

Objective

To characterize the association of decline in estimated GFR with subsequent progression to ESRD with implications for using lesser declines in estimated GFR as potential alternative end points for CKD progression. Because most people with CKD die before reaching ESRD, mortality risk also was investigated.

Data sources and study selection

Individual meta-analysis of 1.7 million participants with 12,344 ESRD events and 223,944 deaths from 35 cohorts in the CKD Prognosis Consortium with a repeate

SUBMITTER: Coresh J 

PROVIDER: S-EPMC4172342 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature