Alpha-synuclein repeat variants and survival in Parkinson's disease.

ABSTRACT:

Objectives

To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).

Methods

Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.

Results

Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01).

Conclus

SUBMITTER: Chung SJ 

PROVIDER: S-EPMC4172351 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature