Combinative in vitro studies and computational model to predict 3D cell migration response to drug insult.

ABSTRACT: The development of drugs to counter diseases related to cell migration has resulted in a multi-billion dollar endeavor. Unfortunately, few drugs have emerged from this effort highlighting the need for new methods to enhance assays to study, analyze and control cell migration. In response to this complex process, computational models have emerged as potent tools to describe migration providing a high throughput and low cost method. However, most models are unable to predict migration response to drug with direct application to in vitro experiments. In addition to this, no model to date has attempted to describe migration in response to drugs while incorporating simultaneously protein signaling, proteolytic activity, and 3D culture. In this paper, we describe an integrated computational appr

SUBMITTER: Maffei JS 

PROVIDER: S-EPMC4172491 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature