Shared signatures of social stress and aging in peripheral blood mononuclear cell gene expression profiles.

ABSTRACT: Chronic social stress is a predictor of both aging-related disease and mortality risk. Hence, chronic stress has been hypothesized to directly exacerbate the process of physiological aging. Here, we evaluated this hypothesis at the level of gene regulation. We compared two data sets of genome-wide gene expression levels in peripheral blood mononuclear cells (PBMCs): one that captured aging effects and another that focused on chronic social stress. Overall, we found that the direction, although not necessarily the magnitude, of significant gene expression changes tends to be shared between the two data sets. This overlap was observable at three levels: (i) individual genes; (ii) general functional categories of genes; and (iii) molecular pathways implicated in aging. However, we also found

SUBMITTER: Snyder-Mackler N 

PROVIDER: S-EPMC4172541 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature