Concept mapping One-Carbon Metabolism to model future ontologies for nutrient-gene-phenotype interactions.

ABSTRACT: Advances in the development of bioinformatic tools continue to improve investigators' ability to interrogate, organize, and derive knowledge from large amounts of heterogeneous information. These tools often require advanced technical skills not possessed by life scientists. User-friendly, low-barrier-to-entry methods of visualizing nutrigenomics information are yet to be developed. We utilized concept mapping software from the Institute for Human and Machine Cognition to create a conceptual model of diet and health-related data that provides a foundation for future nutrigenomics ontologies describing published nutrient-gene/polymorphism-phenotype data. In this model, maps containing phenotype, nutrient, gene product, and genetic polymorphism interactions are visualized as triples of two c

SUBMITTER: Joslin AC 

PROVIDER: S-EPMC4172641 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature