Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?

ABSTRACT: Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield long-lasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient ou

SUBMITTER: Walters Haygood CL 

PROVIDER: S-EPMC4172672 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature