Correlation analysis of liver tumor-associated genes with liver regeneration.

ABSTRACT:

Aim

To study at transcriptional level the similarities and differences of the physiological and biochemical activities between liver tumor (LT) and regenerating liver cells.

Methods

LT-associated genes and their expression changes in LT were obtained from databases and scientific articles, and their expression profiles in rat liver regeneration (LR) were detected using Rat Genome 230 2.0 array. Subsequently their expression changes in LT and LR were compared and analyzed.

Results

One hundred and twenty one LT-associated genes were found to be LR-associated. Thirty four genes were up-regulated, and 14 genes were down-regulated in both LT and regenerating liver; 20 genes up-regulated in LT were down-regulated in regenerating liver; 21 up-regulated genes and 16 down-regu

SUBMITTER: Xu CS 

PROVIDER: S-EPMC4172712 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature