Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity.

ABSTRACT:

Background

Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolism, and excretion. ATP binding cassette (ABC) transport proteins are particularly involved in drug deposition, as they are located at membranes of many uptake and excretory organs and at protective barriers, where they export endogenous and xenobiotic compounds, including pharmaceuticals. In this study, a panel of well-established anti-malarial drugs which may affect drug plasma concentrations was tested for interactions with human ABC transport proteins.

Methods

The interaction of chloroquine, quinine, artemisinin, mefloquine, lumefantrine, atovaquone, dihydroartemisi

SUBMITTER: Rijpma SR 

PROVIDER: S-EPMC4172838 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature