Ontology highlight
ABSTRACT:
SUBMITTER: Fujimuro T
PROVIDER: S-EPMC4173035 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20140924
A set of genes in the posterior end of developing mouse embryos shows oscillatory expression, thereby regulating periodic somite segmentation. Although the mechanism for generating oscillation has extensively been clarified, what regulates the oscillation period is still unclear. We attempted to elongate the oscillation period by increasing the time to transcribe Hes7 in this research. We generated knock-in mice, in which a large intron was inserted into Hes7 3'UTR. The exogenous intron was unex ...[more]