Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation.

ABSTRACT:

Study objectives

To address whether changes in gene expression in blood cells with sleep loss are different in individuals resistant and sensitive to sleep deprivation.

Design

Blood draws every 4 h during a 3-day study: 24-h normal baseline, 38 h of continuous wakefulness and subsequent recovery sleep, for a total of 19 time-points per subject, with every 2-h psychomotor vigilance task (PVT) assessment when awake.

Setting

Sleep laboratory.

Participants

Fourteen subjects who were previously identified as behaviorally resistant (n = 7) or sensitive (n = 7) to sleep deprivation by PVT.

Intervention

Thirty-eight hours of continuous wakefulness.

Measurements and results

We found 4,481 unique genes with a significant 24-h diurnal rhythm during a normal

SUBMITTER: Arnardottir ES 

PROVIDER: S-EPMC4173916 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature