Evolution of lung function during the first year of life in newborn screened cystic fibrosis infants.

ABSTRACT:

Rationale

Newborn screening (NBS) for cystic fibrosis (CF) allows early intervention. Design of randomised controlled trials (RCT) is currently impeded by uncertainty regarding evolution of lung function, an important trial end point in such infants.

Objective

To assess changes in pulmonary function during the first year of life in CF NBS infants.

Methods

Observational longitudinal study. CF NBS infants and healthy controls were recruited between 2009 and 2011. Lung Clearance Index (LCI), plethysmographic lung volume (plethysmographic functional residual capacity (FRCpleth)) and forced expired volume (FEV₀.₅) were measured at 3 months and 1 year of age.

Main results

Paired measurements were obtained from 72 CF infants and 44 controls. At 3 months, CF infants ha

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC4174068 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature