Atrial fibrillation associated with ivabradine treatment: meta-analysis of randomised controlled trials.

ABSTRACT:

Objective

To quantify any risk of atrial fibrillation (AF) associated with ivabradine treatment by meta-analysis of clinical trial data.

Methods

Medline, Embase, Web of Knowledge and the Cochrane central register of controlled trials were searched for double-blinded randomised controlled trials of ivabradine with a minimum follow-up period of 4 weeks. For studies where AF data were unpublished, safety data were obtained from the European Medicines Agency (EMeA) website and personal communications. Studies were appraised for risk of bias using components recommended by the Cochrane Collaboration. Meta-analyses were performed of relative risk of AF and absolute risk difference of AF per year of treatment. The main outcome measure was incident AF during the follow-up period.

SUBMITTER: Martin RI 

PROVIDER: S-EPMC4174120 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature