Characterization of Leukocyte Formin FMNL1 Expression in Human Tissues.

ABSTRACT: Formins are cytoskeleton regulating proteins characterized by a common FH2 structural domain. As key players in the assembly of actin filaments, formins direct dynamic cytoskeletal processes that influence cell shape, movement and adhesion. The large number of formin genes, fifteen in the human, suggests distinct tasks and expression patterns for individual family members, in addition to overlapping functions. Several formins have been associated with invasive cell properties in experimental models, linking them to cancer biology. One example is FMNL1, which is considered to be a leukocyte formin and is known to be overexpressed in lymphomas. Studies on FMNL1 and many other formins have been hampered by a lack of research tools, especially antibodies suitable for staining paraffin-embedded

SUBMITTER: Gardberg M 

PROVIDER: S-EPMC4174630 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature