ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.

ABSTRACT:

Background

Alcohol dependence (AD) is a complex disorder characterized by impaired control over drinking. It is determined by both genetic and environmental factors. The recent approach of genome-wide association study (GWAS) is a powerful tool for identifying complex disease-associated susceptibility alleles, however, a few GWASs have been conducted for AD, and their results are largely inconsistent. The present study aimed to screen the loci associated with alcohol-related phenotypes using GWAS technology.

Methods

A genome-wide association study with the behavior of regular alcohol drinking and alcohol consumption was performed to identify susceptibility genes associated with AD, using the Affymetrix 500K SNP array in an initial sample consisting of 904 unrelated Caucasian

SUBMITTER: Chen XD 

PROVIDER: S-EPMC4174677 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature