Sickle cell trait and incident ischemic stroke in the Atherosclerosis Risk in Communities study.

ABSTRACT:

Background and purpose

Numerous case reports describe stroke in individuals with sickle cell trait (SCT) in the absence of traditional risk factors for cerebrovascular disease. To date, no prospective epidemiological studies have investigated this association.

Methods

A population-based sample of blacks (n=3497; mean age=54 years; female=62%) was followed from 1987 to 2011 in the Atherosclerosis Risk in Communities (ARIC) study, contributing a total of 65 371 person-years. Hazard ratios and incidence rate differences for ischemic stroke were estimated, contrasting SCT to homozygous hemoglobin A. Models were adjusted for age, sex, smoking, diabetes mellitus, hypertension, total cholesterol, atrial fibrillation, and coronary heart disease.

Results

SCT was identified in

SUBMITTER: Caughey MC 

PROVIDER: S-EPMC4174726 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature