Conditional asymmetric linkage disequilibrium (ALD): extending the biallelic r2 measure.

ABSTRACT: For multiallelic loci, standard measures of linkage disequilibrium provide an incomplete description of the correlation of variation at two loci, especially when there are different numbers of alleles at the two loci. We have developed a complementary pair of conditional asymmetric linkage disequilibrium (ALD) measures. Since these measures do not assume symmetry, they more accurately describe the correlation between two loci and can identify heterogeneity in genetic variation not captured by other symmetric measures. For biallelic loci the ALD are symmetric and equivalent to the correlation coefficient r. The ALD measures are particularly relevant for disease-association studies to identify cases in which an analysis can be stratified by one of more loci. A stratified analysis can aid in

SUBMITTER: Thomson G 

PROVIDER: S-EPMC4174944 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature