Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population.

ABSTRACT: Animals in nature are frequently challenged by toxic compounds, from those that occur naturally in plants as a defense against herbivory, to pesticides used to protect crops. On exposure to such xenobiotic substances, animals mount a transcriptional response, generating detoxification enzymes and transporters that metabolize and remove the toxin. Genetic variation in this response can lead to variation in the susceptibility of different genotypes to the toxic effects of a given xenobiotic. Here we use Drosophila melanogaster to dissect the genetic basis of larval resistance to nicotine, a common plant defense chemical and widely used addictive drug in humans. We identified quantitative trait loci (QTL) for the trait using the DSPR (Drosophila Synthetic Population Resource), a panel of mult

SUBMITTER: Marriage TN 

PROVIDER: S-EPMC4174953 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature