The pluripotency factor Nanog is directly upregulated by the androgen receptor in prostate cancer cells.

ABSTRACT:

Background

The Androgen Receptor (AR) is a nuclear hormone receptor that functions as a critical oncogene in all stages of prostate cancer progression, including progression to castration-resistance following androgen-deprivation therapy. Thus, identifying and targeting critical AR-regulated genes is one potential method to block castration-resistant cancer proliferation. Of particular importance are transcription factors that regulate stem cell pluripotency; many of these genes are emerging as critical oncogenes in numerous tumor cell types. Of these, Nanog has been previously shown to increase the self-renewal and stem-like properties of prostate cancer cells. Thus, we hypothesized that Nanog is a candidate AR target gene that may impart castration-resistance.

Methods

We m

SUBMITTER: Kregel S 

PROVIDER: S-EPMC4174985 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature