Predictors of mortality in patients with lacunar stroke in the secondary prevention of small subcortical strokes trial.

ABSTRACT:

Background and purpose

The Secondary Prevention of Small Subcortical Stroke trial (SPS3) recruited participants meeting clinical and radiological criteria for symptomatic lacunes. Individuals randomized to dual antiplatelet therapy with clopidogrel and aspirin had an unanticipated increase in all-cause mortality compared with those assigned to aspirin. We investigated the factors associated with mortality in this well-characterized population.

Methods

We identified independent predictors of mortality among baseline demographic and clinical factors by Cox regression analysis in participants of the SPS3 trial. Separately, we examined the effect on mortality of nonfatal bleeding during the trial.

Results

During a mean follow-up of 3.6 years, the mortality rate was 1.78%

SUBMITTER: Sharma M 

PROVIDER: S-EPMC4175186 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature