Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome.

ABSTRACT:

Background

Autism Spectrum Conditions (ASC) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction, alongside unusually repetitive behaviors and narrow interests. ASC are highly heritable and have complex patterns of inheritance where multiple genes are involved, alongside environmental and epigenetic factors. Asperger Syndrome (AS) is a subgroup of these conditions, where there is no history of language or cognitive delay. Animal models suggest a role for oxytocin (OXT) and oxytocin receptor (OXTR) genes in social-emotional behaviors, and several studies indicate that the oxytocin/oxytocin receptor system is altered in individuals with ASC. Previous studies have reported associations between genetic variations in the OXTR

SUBMITTER: Di Napoli A 

PROVIDER: S-EPMC4175274 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature