Influence of early goal-directed therapy using arterial waveform analysis on major complications after high-risk abdominal surgery: study protocol for a multicenter randomized controlled superiority trial.

ABSTRACT:

Background

Early goal-directed therapy refers to the use of predefined hemodynamic goals to optimize tissue oxygen delivery in critically ill patients. Its application in high-risk abdominal surgery is, however, hindered by safety concerns and practical limitations of perioperative hemodynamic monitoring. Arterial waveform analysis provides an easy, minimally invasive alternative to conventional monitoring techniques, and could be valuable in early goal-directed strategies. We therefore investigate the effects of early goal-directed therapy using arterial waveform analysis on complications, quality of life and healthcare costs after high-risk abdominal surgery.

Methods/design

In this multicenter, randomized, controlled superiority trial, 542 patients scheduled for elective,

SUBMITTER: Montenij L 

PROVIDER: S-EPMC4175278 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature