A novel polymorphism of the GP78 gene is associated with coronary artery disease in Han population in China.

ABSTRACT:

Background

GP78 is a membrane-anchored ubiquitin ligase mediating the degradation of 3-hydroxy-3-methyl-glutaryl-CoA coenzyme A reductase (HMGCR) and Insig-1, which was very essential for the synthesis of cholesterol process. Cholesterol levels have a causal role in the development of cardiovascular disease. The aim of the present study was to assess the association between the human gp78 gene polymorphism and coronary artery disease (CAD) in a Han and Uygur population of China.

Methods

We used two independent case-control studies: a Han population (602 CAD patients and 572 control subjects) and a Uygur population (374 CAD patients and 376 control subjects). All CAD patients and controls were genotyped for the same three single nucleotide polymorphisms (SNPs) (rs731119, rs26

SUBMITTER: Cha E 

PROVIDER: S-EPMC4175632 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature