Deregulation of Hippo kinase signalling in human hepatic malignancies.

ABSTRACT:

Background/aims

Hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and hepatoblastoma (HB) are the main hepatic malignancies with limited treatment options and high mortality. Recent studies have implicated Hippo kinase pathway in cancer development, but detailed analysis of Hippo kinase signalling in human hepatic malignancies, especially CC and HB, is lacking.

Methods

We investigated Hippo kinase signalling in HCC, CC and HB using cells and patient samples.

Results

Increased expression of yes-associated protein (Yap), the downstream effector of the Hippo kinase pathway, was observed in HCC cells, and siRNA-mediated knockdown of Yap resulted in decreased survival of HCC cells. The density-dependent activation of Hippo kinase pathway characteristic of normal cell

SUBMITTER: Li H 

PROVIDER: S-EPMC4175712 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature