NQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysis.

ABSTRACT:

Introduction

A FEW STUDIES HAVE REPORTED AN ASSOCIATION BETWEEN NADP(H): quinine oxidoreductase 1 (NQO1) C609T polymorphism and susceptibility to colorectal cancer (CRC). However, the results were inconsistent rather than conclusive. We performed a meta-analysis to examine this association in various populations.

Material and methods

Eligible articles were identified by a search of several databases up until June 30, 2013. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the association.

Results

Overall, 14 case-control studies with 4,461 cases and 5,474 controls were included in this meta-analysis. The results indicated that the NQO1 C609T polymorphism was significantly associated with CRC susceptibility (summary

SUBMITTER: Zheng B 

PROVIDER: S-EPMC4175766 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature