APOE ε variants increase risk of warfarin-related intracerebral hemorrhage.

ABSTRACT:

Objective

We aimed to assess the effect of APOE ε variants on warfarin-related intracerebral hemorrhage (wICH), evaluated their predictive power, and tested for interaction with warfarin in causing wICH.

Methods

This was a prospective, 2-stage (discovery and replication), case-control study. wICH was classified as lobar or nonlobar based on the location of the hematoma. Controls were sampled from ambulatory clinics (discovery) and random digit dialing (replication). APOE ε variants were directly genotyped. A case-control design and logistic regression analysis were utilized to test for association between APOE ε and wICH. A case-only design and logistic regression analysis were utilized to test for interaction between APOE ε and warfarin. Receiver operating characteristic cu

SUBMITTER: Falcone GJ 

PROVIDER: S-EPMC4176027 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature