Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis.

ABSTRACT:

Background

Basal-like breast cancer is a heterogeneous disease characterized by the expression of basal cell markers, no estrogen or progesterone receptor expression and a lack of HER2 overexpression. Recent studies have linked activation of the Wnt/β-catenin pathway, and its downstream target, Myc, to basal-like breast cancer. Transgenic mice K5ΔNβcat previously generated by our team present a constitutive activation of Wnt/β-catenin signaling in the basal myoepithelial cell layer, resulting in focal mammary hyperplasias that progress to invasive carcinomas. Mammary lesions developed by K5ΔNβcat mice consist essentially of basal epithelial cells that, in contrast to mammary myoepithelium, do not express smooth muscle markers.

Methods

Microarray analysis was used to compare

SUBMITTER: Moumen M 

PROVIDER: S-EPMC4176121 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature