Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action.

ABSTRACT:

Background

Austism spectrum disorder (ASD) is a heterogeneous behavioral disorder or condition characterized by severe impairment of social engagement and the presence of repetitive activities. The molecular etiology of ASD is still largely unknown despite a strong genetic component. Part of the difficulty in turning genetics into disease mechanisms and potentially new therapeutics is the sheer number and diversity of the genes that have been associated with ASD and ASD symptoms. The goal of this work is to use shRNA-generated models of genetic defects proposed as causative for ASD to identify the common pathways that might explain how they produce a core clinical disability.

Methods

Transcript levels of Mecp2, Mef2a, Mef2d, Fmr1, Nlgn1, Nlgn3, Pten, and Shank3 were knocked-

SUBMITTER: Lanz TA 

PROVIDER: S-EPMC4176301 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature