Abnormal hemostatic function one year after orthotopic liver transplantation can be fully attributed to endothelial cell activation.

ABSTRACT:

Background

The long-term risk of thrombotic and vascular complications is elevated in liver transplant recipients compared to the general population. Patients with cirrhosis are in a hypercoagulable status during and directly after orthotopic liver transplantation, but it is unclear whether this hypercoagulability persists over time.

Aim

We aimed to investigate the hemostatic status of liver transplant recipients one year after transplantation.

Methods

We prospectively collected blood samples of 15 patients with a functioning graft one year after orthotopic liver transplantation and compared the hemostatic status of these patients with that of 30 healthy individuals.

Results

Patients one year after liver transplantation had significantly elevated plasma levels

SUBMITTER: Arshad F 

PROVIDER: S-EPMC4176425 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature