Chronic natural killer lymphoproliferative disorders: characteristics of an international cohort of 70 patients.

ABSTRACT:

Background

The 2008 World Health Organization (WHO) classification distinguishes three entities among the large granular lymphocytic leukemia (LGL leukemia): T-cell LGL leukemia (T-LGL leukemia), aggressive natural killer (NK) cell leukemia, and chronic NK lymphoproliferative disorders (LPD), the later considered as a provisional entity. Only a few and small cohorts of chronic NK LPD have been published.

Patients and methods

We report here clinicobiological features collected retrospectively from 70 cases of chronic NK LPD, and compared with those of T-LGL leukemia.

Results

There were no statistical differences between chronic NK LPD and T-LGL leukemia concerning median age [61 years (range 23-82 years)], organomegaly (26%), associated autoimmune diseases (24%), and a

SUBMITTER: Poullot E 

PROVIDER: S-EPMC4176455 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature