Applying Convergent Immunity to Innovative Vaccines Targeting Staphylococcus aureus.

ABSTRACT: Recent perspectives forecast a new paradigm for future "third generation" vaccines based on commonalities found in diverse pathogens or convergent immune defenses to such pathogens. For Staphylococcus aureus, recurring infections and a limited success of vaccines containing S. aureus antigens imply that native antigens induce immune responses insufficient for optimal efficacy. These perspectives exemplify the need to apply novel vaccine strategies to high-priority pathogens. One such approach can be termed convergent immunity, where antigens from non-target organisms that contain epitope homologs found in the target organism are applied in vaccines. This approach aims to evoke atypical immune defenses via synergistic processes that (1) afford protective efficacy; (2) target an epitope from

SUBMITTER: Yeaman MR 

PROVIDER: S-EPMC4176462 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature