Role of oxygen and the OxyR protein in the response to iron limitation in Rhodobacter sphaeroides.

ABSTRACT:

Background

High intracellular levels of unbound iron can contribute to the production of reactive oxygen species (ROS) via the Fenton reaction, while depletion of iron limits the availability of iron-containing proteins, some of which have important functions in defence against oxidative stress. Vice versa increased ROS levels lead to the damage of proteins with iron sulphur centres. Thus, organisms have to coordinate and balance their responses to oxidative stress and iron availability. Our knowledge of the molecular mechanisms underlying the co-regulation of these responses remains limited. To discriminate between a direct cellular response to iron limitation and indirect responses, which are the consequence of increased levels of ROS, we compared the response of the α-proteobact

SUBMITTER: Remes B 

PROVIDER: S-EPMC4176601 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature