Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

ABSTRACT:

Background

The genetic risk factors for susceptibility to chronic obstructive pulmonary disease (COPD) are still largely unknown. Additional genetic variants are likely to be identified by genome-wide association studies in larger cohorts or specific subgroups. We sought to identify risk loci for moderate to severe and severe COPD with data from several cohort studies.

Methods

We combined genome-wide association analysis data from participants in the COPDGene study (non-Hispanic white and African-American ethnic origin) and the ECLIPSE, NETT/NAS, and Norway GenKOLS studies (self-described white ethnic origin). We did analyses comparing control individuals with individuals with moderate to severe COPD and with a subset of individuals with severe COPD. Single nucleotide polymo

SUBMITTER: Cho MH 

PROVIDER: S-EPMC4176924 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature