Analysis of multiple genetic polymorphisms in aggressive-growing and slow-growing abdominal aortic aneurysms.

ABSTRACT:

Background

The natural history of abdominal aortic aneurysms (AAAs) suggests that some remain slow in growth rate whereas many develop a more accelerated growth rate and reach a threshold for intervention. We hypothesized that different mechanisms are responsible for AAAs that remain slow growing and never become actionable vs the aggressive AAAs that require intervention and may be reflected by distinct associations with genetic polymorphisms.

Methods

AAA growth rate was determined from serial imaging data in 168 control and 141 AAA patients with ultrasound or computed tomography imaging studies covering ∼5 years. Genetic polymorphisms all previously reported as showing a significant correlation with AAA with functional effects on the expression or function were determined

SUBMITTER: Duellman T 

PROVIDER: S-EPMC4176942 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature