'Silent' mitral cells dominate odor responses in the olfactory bulb of awake mice.

ABSTRACT: How wakefulness shapes neural activity is a topic of intense discussion. In the awake olfactory bulb, high activity with weak sensory-evoked responses has been reported in mitral/tufted cells (M/TCs). Using blind whole-cell recordings, we found 33% of M/TCs to be 'silent', yet still show strong sensory responses, with weak or inhibitory responses in 'active' neurons. Thus, a previously missed M/TC subpopulation can exert powerful influence over the olfactory bulb.

SUBMITTER: Kollo M 

PROVIDER: S-EPMC4176944 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature