Reconstruction and modeling protein translocation and compartmentalization in Escherichia coli at the genome-scale.

ABSTRACT:

Background

Membranes play a crucial role in cellular functions. Membranes provide a physical barrier, control the trafficking of substances entering and leaving the cell, and are a major determinant of cellular ultra-structure. In addition, components embedded within the membrane participate in cell signaling, energy transduction, and other critical cellular functions. All these processes must share the limited space in the membrane; thus it represents a notable constraint on cellular functions. Membrane- and location-based processes have not yet been reconstructed and explicitly integrated into genome-scale models.

Results

The recent genome-scale model of metabolism and protein expression in Escherichia coli (called a ME-model) computes the complete composition of the prote

SUBMITTER: Liu JK 

PROVIDER: S-EPMC4177180 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature